Experts believe that stimulation of the histamine receptor aids in the process of waking up.ĭoxepin (Silenor) is a tricyclic antidepressant medication that acts on the histamine receptor. ![]() Histamine is a neurotransmitter that plays an important role in regulating the sleep-wake cycle. The recommended dose for most adults is 10 mg, but older adults and people with low body weights may only need 5 mg. It has not been shown to increase total sleep time or decrease the number of awakenings. Zaleplon (Sonata): Studies suggest that this medication decreases the time it takes to fall asleep.A doctor can increase the dose to a maximum of 3 mg. The recommended starting dose of Lunesta is 1 mg, taken immediately before bedtime. Eszopiclone (Lunesta): This medication has been shown in clinical trials to decrease the time it takes to fall asleep and to improve the ability to stay asleep.The medication is also available in an extended-release tablet under the brand name Ambien CR. People should take it right before bedtime. The prescribing label recommends a starting dose of 5 milligrams (mg) for females and 5 mg or 10 mg for males. Zolpidem (Ambien): Doctors prescribe this medication for insomnia that is characterized by difficulties falling asleep.This means that they can lead to misuse, dependence, and withdrawal.Įxamples of nonbenzodiazepine BZRA oral medications for the short-term treatment of insomnia include: In addition, nonbenzodiazepine BZRAs are classified as Schedule IV controlled substances. A person should stop taking their medication immediately if they experience any complex sleep behaviors. Some people who take nonbenzodiazepine BZRAs experience “complex sleep behaviors.” These include sleep-walking, sleep-driving, and participating in other activities while not fully awake. For this reason, a person should not operate a vehicle within 8 hours of taking this type of medication. However, nonbenzodiazepine BZRAs still carry side effects, including dizziness and drowsiness. These medications help reduce some of the side effects common with benzodiazepines. In the 1990s, nonbenzodiazepine BZRAs entered the market. Some studies suggest that their benefits decline after 4 weeks of use.Įxamples of BZRAs that are FDA-approved for treating insomnia include: They are also likely to lead to dependence. These drugs can increase the risk of falls, vehicle accidents, memory problems, and daytime sedation, especially among older adults. The brain naturally releases GABA to promote sleep at nighttime.īZRAs include both benzodiazepine hypnotics and nonbenzodiazepine BZRAs.įor decades, benzodiazepine hypnotics were the only drugs with FDA approval for treating insomnia. GABA is a chemical that inhibits, or slows, the brain’s functions. Benzodiazepine receptor agonistsīenzodiazepine receptor agonists (BZRAs) target a specific part of the brain and may increase a neurotransmitter called gamma-aminobutyric acid (GABA). The sections below look at these categories in more detail. Medications for treating insomnia fall into one of several categories. People should only take them before bed when they have at least 7 hours to sleep. ![]() These medications may have side effects, including drowsiness and dizziness. However, it is important to talk with a doctor before taking a sleep medication. Medications can help some people with chronic insomnia. Most medications only have approval for short-term use. Some people use medications alongside CBTi. Other recommended treatments for insomnia include relaxation techniques and exercise. The app takes users through a series of lessons and exercises to encourage sleep. Somryst is a new, Food and Drug Administration (FDA)-approved prescription treatment that combines CBTi with an app-based delivery platform.
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